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PGT- Preimplantation genetic testing

What is PGT?

  • Preimplantation Genetic Testing (PGT) is a technique used to screen embryos for genetic abnormalities before transferring them to the uterus during an In Vitro
    Fertilization (IVF) cycle. This testing helps ensure that only healthy embryos with the
    correct number of chromosomes or without specific genetic mutations are
    implanted.

 

  • Procedure:
    On day 5 or 6 of embryo development (blastocyst stage), a few cells are carefully
    biopsied from each embryo. The biopsied cells are sent to a genetic laboratory for
    analysis. The remaining embryo is cryopreserved (frozen) while awaiting test results.

 

  • Indications:
    •  Recurrent Pregnancy Loss
    •  Advanced Maternal Age
    •  Genetic Diseases
    •  Repeated IVF Failures

Key Features of PGT

  1. Enhanced Embryo Selection: Allows for the selection of embryos free of genetic abnormalities, increasing the chances of a successful pregnancy.
  2. Improved IVF Success Rates: Leads to higher implantation rates and reduced risk of miscarriage.
  3. Genetic Disease Prevention: Prevents the transmission of inherited genetic disorders to offspring.
  4. Reduced Risk of Aneuploidies: Identifies and excludes embryos with abnormal chromosome numbers.
  5. Personalized Medicine: Offers a tailored approach to fertility treatment based on genetic analysis.
  6. Early Detection: Provides early detection of genetic issues, allowing informed decision-making.
  7. Peace of Mind: Gives couples confidence in the health of their embryos before implantation.
  8. Cryopreservation: Allows for the freezing of healthy embryos for future use, providing multiple chances for successful implantation.
  9. Comprehensive Reporting: Offers detailed reports on the genetic status of each embryo.
  10. Ethical Considerations: Adheres to ethical guidelines to ensure responsible use of genetic testing in reproductive medicine.

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